Series of Cardiology Research

Series of Cardiology research

Research Article

Clinical Correlation of Left Ventricular Geometric Patterns at King Abdulaziz Hospital Al-Ahsa Eastern Province

AlTaweel M*, Alshaikh Husain M, Gado W, Alghasham KZ, Faqeehi R, Al-Raimi S, AlMukhaylid S, Alsultan NF, Alharbi FS, Altuwaim IN, Alibrahim KI, Aleid NF and Soliman AF

Clinical Correlation of Left Ventricular Geometric Patterns at King Abdulaziz Hospital Al-Ahsa Eastern Province Read More »

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AlTaweel M, Alshaikh Husain M, Gado W, et al. Clinical correlation of left ventricular geometric patterns at King Abdulaziz Hospital Al-Ahsa Eastern Province. Series Cardiol Res. 2023;5(1):29-42.
Objective: Exploring the prevalence of alteration in left ventricular (LV) geometry by echocardiography and their correlation with cardiovascular (CV) risk factors and cardiovascular diseases (CVD). Background: Alterations in LV geometry, by echocardiography, is an important prognostic determinant of CVD morbidity and mortality. Yet it is an underutilized tool and has yet to be established in laboratories. Methods: Left ventricular mass index (LVMI) and relative wall thickness (RWT) were calculated by M-mode echocardiography. Patients were classified into four groups based on RWT and LVMI: normal geometry, concentric remodeling (CR), eccentric left ventricular hypertrophy (eLVH), and concentric left ventricular hypertrophy (cLVH). Results: LV geometry patterns revealed normal geometry prevalence (43.46%), followed by CR (30.76%). The commonest CV risk factor was hypertension (HTN) (85%), followed by diabetes mellitus (DM) (72%). A strong association was identified between CVD and LV geometry changes (p-value < 0.005). CVD prevalence among total patients was 66.5% within this group; coronary artery disease (CAD) prevalence was 55.5% (p-value < 0.029), and heart failure (HF) prevalence was 29.6% (p-value < 0.001). Conclusion: We strongly reinforce routine echocardiograms in determining LVM, RWT, and LV geometry patterns. It is an important, underutilized diagnostic and prognostic tool in risk stratification of patients with CVD and altered LV geometry and mass. Future studies for incorporating LVM and RWT in clinical decision algorithms are warranted.
Article DOI: 10.54178/2768-5985.2023a6
Case Report

Case Report on Hypertrophic Cardiomyopathy – How to Detect it in Middle-Aged Amateur Athletes

Bolognesi M

Case Report on Hypertrophic Cardiomyopathy – How to Detect it in Middle-Aged Amateur Athletes Read More »

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Bolognesi M. Case report on hypertrophic cardiomyopathy - how to detect it in middle-aged amateur athletes. Series Cardiol Res. 2023;5(1):10-14.
The safety of exercise in athletes with hypertrophic cardiomyopathy (HCM) and the emphasis on shared decision-making has led to the updating of the most recent recommendations, which have reduced restrictions on exercise and competitive sports activity in this population. This case report confirms that obstructive HCM reduces fitness in the amateur athlete, even if paucisymptomatic or asymptomatic, leading to a physical limitation to practicing high-intensity sports. It also points out how it is possible to differentiate physiological left ventricular (LV) hypertrophy from morphologically mild but pathological one, outlining the clinical aspects from a morphological and functional point of view.
Article DOI: 10.54178/2768-5985.2023a2
Review Article

Should We be Screening for Cardiovascular Complications in Patients with Primary Hyperparathyroidism – A Narrative Review of the Current Evidence

Olaogun I

Should We be Screening for Cardiovascular Complications in Patients with Primary Hyperparathyroidism – A Narrative Review of the Current Evidence Read More »

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Olaogun I. Should we be screening for cardiovascular complications in patients with primary hyperparathyroidism - a narrative review of the current evidence. Series Cardiol Res. 2023;5(1):1-9.
There are many evidence that links cardiovascular (CV) complications to primary hyperparathyroidism (PHPT). However, these CV complications have never been considered an indication for surgical management of PHPT, and even some studies showed that in those that have surgical treatment, there is no evidence of reversibility of the CV complications. Despite the reasonable explanation of the underlined mechanisms involved in these complications in the literature that prove the increased CV associations, there are some conflicting data that showed no or even reduced associations and this has been a matter of debate for decades. The CV complications reported to have associations with PHPT include cardiac (left ventricular remodeling, coronary vascular disease, calcifications), vascular including hypertension (HTN), atherosclerosis, cardiometabolic complications including insulin resistance, diabetes mellitus, and CV mortality. This article reviewed the strength of current evidence and the author’s stand on whether it is worth including in the guideline as an indication for current treatment.
Article DOI: 10.54178/2768-5985.2023a1
Research Article

Systolic Heart Failure and Optimization of Medical Therapy: A Quality Improvement Study

Lantz R

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Lantz R. Systolic heart failure and optimization of medical therapy: a quality improvement study. Series Cardiol Res. 2022;4(1):34-39.
Introduction: Congestive heart failure (CHF) accounts for significant medical costs and patient mortality. There are ways to mitigate these parameters by providing patient and provider education, optimizing medications, and applying life-saving devices with a referral for a left ventricular assist device (LVAD) when appropriate. We retrospectively observed the charts of 40 patients at our Dayton Veterans Affairs Medical Center (VAMC) for areas of improvement. Methods: Charts were manually reviewed over 2019 for ejection fraction (EF) at the time of diagnosis and ischemic cardiomyopathy (ICM) vs. nonischemic cardiomyopathy (NICM) etiology of heart failure. Information on the titration of beta-blockers (BB), angiotensin-converting enzyme inhibitors (ACE-I), angiotensin receptor blockers (ARBs), and advanced heart failure medications was collected. Readmission rates and heart failure follow-up appointment rates were gathered, and further details were investigated regarding the application of a life vest and automatic implantable cardioverter-defibrillator (AICD) when clinically appropriate. Results: Median EF for patients was 34%, consistent with systolic heart failure. 65% of patients had ICM. For medications, BB was maximally titrated for 85% of patients within a wide data range. ACE-I/ARBs titration was appropriate in 75% of patients. An average of 4.7 dose adjustments for BB and 3.6 dose adjustments for ACE-I/ARBs occurred. Advanced CHF medications were rarely prescribed. Exacerbation rates were 60%, from 1–5 readmissions and an average of 1.07 readmissions. 98% of patients received CHF-specific follow-up after each CHF admission. 60% were eligible for advanced life support devices, 25% were offered life vests, and 62% were offered AICD. No patient was referred to a tertiary center for LVAD. Conclusion: We should work towards 100% medication titration to improve outcomes, especially BB which is known to have morbidity value. We can continue to reduce heart failure readmission rates by providing patient and provider education and continuing to do well at heart failure follow-up appointments. Life vest and AICD should be offered more consistently, and tertiary referral to receive LVAD should remain offered per standard of care.
Article DOI: 10.54178/2768-5985.2022a7
Research Article

Cardiovascular Compromise in Pediatrics in the Times of COVID-19: SARS-CoV-2 Infection and Kawasaki Disease

Mariño C *, Taipe F, Nario V and Culqui K

Cardiovascular Compromise in Pediatrics in the Times of COVID-19: SARS-CoV-2 Infection and Kawasaki Disease Read More »

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Mariño C, Taipe F, Nario V, et al. Cardiovascular compromise in pediatrics in the times of COVID-19: SARS-CoV-2 infection and Kawasaki disease. Series Cardiol Res. 2022;4(1):24-33.
Introduction: The pandemic caused by the new SARS-CoV-2 virus has reported an increase in morbidity and mortality worldwide during the years 2020 to 2022. Many pediatric infections have been reported as mild. The cardiovascular complications due to COVID-19 described in the literature are mainly in adults, however, reports in the pediatric population have been less frequent. Objective: To describe the clinical characteristics and evolution of patients treated in two centers with cardio-pediatric care services who presented cardiovascular involvement during the COVID-19 pandemic related to the presence of SARS-CoV-2 infection and Kawasaki disease (KD). Materials and Methods: Through a descriptive, retrospective study, the medical records, electrocardiographic and echocardiographic studies were reviewed in both groups of patients between May 2020 and May 2022 at the National Institute of Child Health and Alberto Sabogal Hospital. None of the cases had a history of previous structural heart disease. Results: The patients studied were 31 in total, with 21 cases of COVID-19 (SARS-CoV-2 infection) and 10 of KD. The female sex predominated, with an average age of 6.2 years (COVID-19) and 2.9 years (Kawasaki). In the echocardiogram, mild pericardial effusion was the most common finding. Coronary alterations were found in 60% of patients with KD and in only 18% of COVID-19 cases. We found 15 patients who met the criteria for the so-called multisystem syndrome (MIS-C) among COVID-19 cases, 5 of them with hemodynamic compromise. Conclusion: During the COVID-19 pandemic, the clinical picture in both groups: SARS-CoV-2 infection and KD presented some similar characteristics, mainly in relation to coronary involvement (greater involvement in KD), and in the evolution, a greater hemodynamic compromise was evidenced in cases of SARS-CoV-2 infection but without associated mortality.
Article DOI: 10.54178/2768-5985.2022a6
Brief Communication

The Importance of Time-Domain HRV Analysis in Cardiac Health Prediction

Chattopadhyay S

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Chattopadhyay S. The importance of time-domain HRV analysis in cardiac health prediction. Series Cardiol Res. 2022;4(1):19-23.
Heart rate variability (HRV) is defined as the momentary variation in the end heart rate (EHR) estimated at various intervals (time domains), such as from 2 min (ultra-short HRV) to 24 h (long HRV) intervals. The R peak interval (RRI) between two consecutive beats called momentary heart rate (MHR) provides insight into the impending cardiovascular risk and not the EHR. The autonomic nervous system (ANS) is in charge of maintaining physiological homeostasis by keeping the MHR and in turn the EHR within the normal range of 60–100 bpm. ANS has two components – the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS). The former increases HR (reduces RRI) while the latter reduces it. Therefore, the RR time-domain-HRV-data (THD) provides better insight into overall health than the EHR. Six types of THDs, e.g., mean-HR, mean-RR, SDNN, SDHR, RMSSD, and pNN50 are discussed in this article.
Article DOI: 10.54178/2768-5985.2022a5
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