Chi S. Piezo channels in cardiac function: mechanotransduction, challenges, and future perspectives. Series Cardiol Res. 2025;7(1):1-4.
The study of Piezo channels has significantly advanced our understanding of mechanotransduction in various biological systems, including the cardiovascular system. These channels, particularly Piezo1, have been implicated in a range of physiological and pathological processes, such as heart function, vascular tone regulation, and response to mechanical stress. Despite their crucial role in cardiovascular health, several challenges remain in fully elucidating the mechanisms by which Piezo channels mediate heart function. This review explores the frontiers of Piezo channel research, with a focus on the challenges that hinder progress and potential future directions.
