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Series of Cardiology Research

Current Issue | Volume 5 Issue 1 | JSCR

Case Report

Incessant Ectopic Atrial Tachycardia Accompanied by Unusual Neurological Manifestations – Case Report and Literature Review

Alomayrin N, M Alshaikh Hussain, AlMusaad A, Al muaiweed R, Aljohani S, and AlTaweel M *

Incessant Ectopic Atrial Tachycardia Accompanied by Unusual Neurological Manifestations – Case Report and Literature Review Read More »

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Alomayrin N, M Alshaikh Hussain, AlMusaad A, et al. Incessant ectopic atrial tachycardia accompanied by unusual neurological manifestations - case report and literature review. Series Cardiol Res. 2023;5(1):90-98.
Incessant ectopic atrial tachycardia (EAT) is well-known in the electrophysiology world. However, once accompanied by neurological manifestations, hence is a dilemma. We are reporting a 26-year-old male presenting with incessant symptomatic EAT. Once cardioverted, he began to manifest cardiovascular stroke clinical symptoms. Further objective investigation revealed no evidence of cardioembolic stroke. Our aim of this case report is to explore if there is a true correlation between EAT and possible neurological association and open further guidelines related to research.
Article DOI: 10.54178/2768-5985.2023a11
Case Report

Hydroxycobalamin Administration in the Treatment of Calcium Channel Blocker-Induced Vasoplegia: A Case Report

Crawley RM*, Baty SR and Williams B

Hydroxycobalamin Administration in the Treatment of Calcium Channel Blocker-Induced Vasoplegia: A Case Report Read More »

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Crawley RM, Baty SR, Williams B. Hydroxycobalamin administration in the treatment of calcium channel blocker-induced vasoplegia: a case report. Series Cardiol Res. 2023;5(1):85-89.
Calcium channel blocker (CCB)-induced vasoplegia syndrome is an emergent, life-threatening complication that can occur refractory to traditional therapy in the treatment of an acute CCB overdose. We present a case of acute co-ingestion of many prescription medications, including amlodipine and escitalopram. The patient presented with hemodynamic instability that persisted despite conventional therapies. Hydroxycobalamin (HCO) therapy was initiated, resulting in hemodynamic and clinical improvement. We highlight the unique presentation of this case and the potential benefits associated with HCO administration. Key Points: This case demonstrates the potential benefits of HCO administration in CCB-induced vasoplegia syndrome. Given the significant morbidity and mortality associated with CCB toxicity, HCO may provide considerable benefit in patients with hemodynamic instability refractory to standard treatment modalities.
Article DOI: 10.54178/2768-5985.2023a10
Research Article

The Role of Deuterium 2H in the Pathogenesis of Heart Failure as Deduced by Food Studies from Six Individual Cases

Jones EC*, Phelps JE, Maddox G and Jardet CL

The Role of Deuterium 2H in the Pathogenesis of Heart Failure as Deduced by Food Studies from Six Individual Cases Read More »

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Jones EC, Phelps JE, Maddox G, et al. The role of deuterium 2H in the pathogenesis of heart failure as deduced by food studies from six individual cases. Series Cardiol Res. 2023;5(1):56-84.
Heart failure results from the loss of structural integrity of the heart and/or a decrease in the rate of maximal ATP production. In cases of relatively preserved structural integrity, a decrease in ATP production in the mitochondria leads to a decrease in the cardiac stroke volume, thereby increasing the heart rate required to maintain the cardiac output. For many years, the exact location of this defect in the metabolic energy cycle remained elusive. Evidence is presented here to show that it is not a single metabolic substrate involved but rather the heavy isotope of hydrogen 2H, deuterium, that is jamming the ATP nanomotors slowing the rate of ATP production. During the digestion of a meal, the cardiac heart rate is shown to be very sensitive to the level of deuterium contained in the fatty acids recently consumed. During strenuous exercise in the fasting state, the enzyme adipose triglyceride lipase (ATGL) is found to mobilize the highest deuterium triglycerides more rapidly than the healthier lower deuterium triglycerides, converting the adipose tissue into a deuterium-depleted energy pool. This is believed to contribute to the low resting heart rates frequently observed in athletes. In vulnerable individuals, i.e., those weakened by disease(s) or space explorers in a weightless environment, the decreased ability to perform strenuous exercise leads to higher deuterium levels in their adipose tissue compromising their ATP production. In these individuals, maintaining healthy deuterium levels is best achieved by an increased intake of lower deuterium-containing foods.
Article DOI: 10.54178/2768-5985.2023a9
Clinical Research

Implementing a New Remote Monitoring Program in the Developing World – The Cleveland Clinic Abu Dhabi Experience

Almuti K, AlJaabari M, McCutchon K*, da Costa S, Pais R, Gancinho A and Shafiei F

Implementing a New Remote Monitoring Program in the Developing World – The Cleveland Clinic Abu Dhabi Experience Read More »

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Almuti K, AlJaabari M, McCutchon K, et al. Implementing a new remote monitoring program in the developing world - The Cleveland Clinic Abu Dhabi experience. Series Cardiol Res. 2023;5(1):46-55.
Background: Remote monitoring (RM) for cardiac implantable electronic devices (CIED) is a class 1A recommendation by expert consensus. RM incorporation into CIED management allows for early detection of abnormalities, improved patient satisfaction, and enhanced device clinic efficiency. Cleveland Clinic Abu Dhabi (CCAD) established the first RM program in the United Arab Emirates in 2015, with over 1000 patients enrolled. We report patient RM compliance as an indicator of the overall benefit of our service, aiming to encourage the widespread application of RM technology in the Middle East and other emerging markets. Objective: To detail the implementation and efficacy of RM service for CIED patients at CCAD to be modeled after as the standard of care for the region. Methods: Patients are enrolled in RM before hospital discharge and undergo device and wound checks one week later in the device clinic. Additional patient education is provided at that time. Subsequent follow-up includes routine in-person evaluations as well as scheduled RM transmissions. Patient compliance is measured as the proportion of received RM transmissions in relation to all scheduled transmissions. Results: A total of 1084 patients were enrolled in RM between December 2015 and May 2022. The overall RM compliance rate at 1-year post-implant was 85%. Conclusion: Our study shows that the establishment of a large-scale RM program in the Middle East region is feasible and associated with excellent patient participation and compliance. We encourage RM integration as the standard of care for CIED patients in our region and areas of the world where such integration has been lagging.
Article DOI: 10.54178/2768-5985.2023a8
Research Article

Clinical Correlation of Left Ventricular Geometric Patterns at King Abdulaziz Hospital Al-Ahsa Eastern Province

AlTaweel M*, Alshaikh Husain M, Gado W, Alghasham KZ, Faqeehi R, Al-Raimi S, AlMukhaylid S, Alsultan NF, Alharbi FS, Altuwaim IN, Alibrahim KI, Aleid NF and Soliman AF

Clinical Correlation of Left Ventricular Geometric Patterns at King Abdulaziz Hospital Al-Ahsa Eastern Province Read More »

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AlTaweel M, Alshaikh Husain M, Gado W, et al. Clinical correlation of left ventricular geometric patterns at King Abdulaziz Hospital Al-Ahsa Eastern Province. Series Cardiol Res. 2023;5(1):29-42.
Objective: Exploring the prevalence of alteration in left ventricular (LV) geometry by echocardiography and their correlation with cardiovascular (CV) risk factors and cardiovascular diseases (CVD). Background: Alterations in LV geometry, by echocardiography, is an important prognostic determinant of CVD morbidity and mortality. Yet it is an underutilized tool and has yet to be established in laboratories. Methods: Left ventricular mass index (LVMI) and relative wall thickness (RWT) were calculated by M-mode echocardiography. Patients were classified into four groups based on RWT and LVMI: normal geometry, concentric remodeling (CR), eccentric left ventricular hypertrophy (eLVH), and concentric left ventricular hypertrophy (cLVH). Results: LV geometry patterns revealed normal geometry prevalence (43.46%), followed by CR (30.76%). The commonest CV risk factor was hypertension (HTN) (85%), followed by diabetes mellitus (DM) (72%). A strong association was identified between CVD and LV geometry changes (p-value < 0.005). CVD prevalence among total patients was 66.5% within this group; coronary artery disease (CAD) prevalence was 55.5% (p-value < 0.029), and heart failure (HF) prevalence was 29.6% (p-value < 0.001). Conclusion: We strongly reinforce routine echocardiograms in determining LVM, RWT, and LV geometry patterns. It is an important, underutilized diagnostic and prognostic tool in risk stratification of patients with CVD and altered LV geometry and mass. Future studies for incorporating LVM and RWT in clinical decision algorithms are warranted.
Article DOI: 10.54178/2768-5985.2023a6
Case Report

Case Report on Hypertrophic Cardiomyopathy – How to Detect it in Middle-Aged Amateur Athletes

Bolognesi M

Case Report on Hypertrophic Cardiomyopathy – How to Detect it in Middle-Aged Amateur Athletes Read More »

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Bolognesi M. Case report on hypertrophic cardiomyopathy - how to detect it in middle-aged amateur athletes. Series Cardiol Res. 2023;5(1):10-14.
The safety of exercise in athletes with hypertrophic cardiomyopathy (HCM) and the emphasis on shared decision-making has led to the updating of the most recent recommendations, which have reduced restrictions on exercise and competitive sports activity in this population. This case report confirms that obstructive HCM reduces fitness in the amateur athlete, even if paucisymptomatic or asymptomatic, leading to a physical limitation to practicing high-intensity sports. It also points out how it is possible to differentiate physiological left ventricular (LV) hypertrophy from morphologically mild but pathological one, outlining the clinical aspects from a morphological and functional point of view.
Article DOI: 10.54178/2768-5985.2023a2

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