Chi S. The role of Piezo1 channels in cardiovascular function: mechanotransduction in the heart and blood vessels. Series Cardiol Res. 2025;7(1):1-4.
Piezo1 channels are mechanosensitive ion channels critical for translating mechanical forces into cellular signals in the cardiovascular system. They regulate heart function by influencing cardiomyocyte contractility and arrhythmogenesis and play a key role in vascular function by modulating endothelial and smooth muscle cell responses to mechanical stimuli. Dysregulation of Piezo1 can contribute to conditions such as arrhythmias, heart failure, and vascular diseases. Despite advancements in understanding Piezo1, challenges remain in studying their mechanisms and developing targeted therapies. Future research into Piezo1’s signaling pathways, the development of selective modulators, and exploring neurovascular interactions hold promise for therapeutic innovations.
